Backpacking Across South America: Tips and Must-Visit Locations
20 Jun 2025
Read Time: 4 min read

South America offers an exciting blend of culture, history, and natural beauty, making it a top destination for backpackers. From the jungles of the Amazon to the peaks of the Andes, this continent is packed with adventure. Whether you're traveling for a few weeks or a few months, here are some tips and must-visit locations to make your backpacking trip across South America unforgettable.

South America is vast, and the best way to explore it is with a well-thought-out plan. Consider the time you have available and the kind of experiences you want to have—whether it's exploring vibrant cities, hiking through mountains, or experiencing remote rural areas.
Start by deciding on the countries you want to visit. Peru, Argentina, Chile, and Brazil are some of the most popular countries for backpackers. If you have the time, you can also venture into Bolivia, Colombia, Ecuador, and beyond. Planning your route around regional travel hubs like Lima, Buenos Aires, and Santiago will help streamline your journey.
Pack Light and SmartWhen backpacking, packing light is key. You'll be carrying your belongings through various environments, from humid rainforests to cold mountain climates, so bring versatile clothing that can be layered. Focus on packing light, practical items such as sturdy shoes for hiking, a rain jacket, sunscreen, and a hat for sun protection.
Additionally, a good-quality backpack, lightweight camping gear, and a portable charger will make your journey more comfortable. Don’t forget to bring a first-aid kit, especially if you’re trekking through remote areas. And be mindful of the baggage limits on buses and planes, which may vary between countries.
Machu Picchu is one of South America’s most iconic destinations, and for good reason. The ancient Incan city set in the Andean mountains is a bucket-list experience for any backpacker. Whether you choose to hike the Inca Trail or take the train to the site, the experience of standing among the stone ruins with panoramic views of the surrounding peaks is truly unforgettable.
Don’t forget to book your entry tickets and transportation in advance, especially during peak season, as access to Machu Picchu is limited. Also, try to visit early in the morning or later in the afternoon to avoid the crowds.

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The Salar de Uyuni in Bolivia is the world’s largest salt flat and an essential stop on a South American backpacking trip. It’s a surreal landscape that stretches endlessly, creating the illusion of walking on the sky, especially during the rainy season when the flats turn into a giant mirror.
For a truly unforgettable experience, take a 3-day tour of the salt flats, which includes exploring the flats themselves, as well as nearby attractions like the Eduardo Avaroa National Park, geysers, and hot springs. Be sure to dress in layers, as temperatures can fluctuate dramatically throughout the day.
Rio de Janeiro, BrazilKnown for its vibrant culture, beaches, and the famous Christ the Redeemer statue, Rio de Janeiro is a must-visit for any backpacker. The city's lively atmosphere, stunning landscapes, and world-class nightlife make it an exciting stop on your South American journey.
Take a hike up to Sugarloaf Mountain for breathtaking views of the city, or spend a day lounging on the iconic Copacabana or Ipanema beach. If you’re visiting during Carnival, don’t miss the chance to experience this spectacular event filled with music, dancing, and parades.
Patagonia, Argentina & ChileIf you’re looking for dramatic landscapes and outdoor adventure, Patagonia should be at the top of your list. This region at the southern tip of South America is famous for its stunning national parks, glaciers, and towering peaks.
Trek the famous W Circuit in Torres del Paine National Park in Chile or visit Los Glaciares National Park in Argentina, home to the massive Perito Moreno Glacier. Patagonia is perfect for backpackers who enjoy hiking, wildlife spotting, and being immersed in nature. Don’t forget to pack warm clothes, as the weather can be unpredictable, even in summer.
Cartagena, ColombiaCartagena is a charming city on Colombia’s Caribbean coast that offers a mix of history, culture, and stunning beaches. The city is famous for its colonial architecture, cobblestone streets, and vibrant nightlife. Wander through the historic walled city, explore the colorful streets, or relax at one of the nearby beaches.
Cartagena also offers great food, with street vendors selling fresh seafood and local specialties like arepas. Take a boat trip to the nearby Rosario Islands, known for their crystal-clear waters and coral reefs—perfect for snorkeling.
Quito, EcuadorEcuador’s capital, Quito, is a UNESCO World Heritage Site known for its well-preserved colonial architecture and stunning views of the surrounding Andes mountains. The city offers a perfect blend of history, culture, and nature.
Take a stroll through the historic old town, visit the famous Mitad del Mundo (Middle of the World) monument, or take a cable car ride to the top of Pichincha Volcano for panoramic views of the city and beyond. Quito also serves as a great base for exploring nearby natural attractions, such as the Amazon rainforest or the Cotopaxi National Park.
ConclusionSouth America is a backpacker’s paradise, with so much to offer for those willing to venture off the beaten path. From ancient ruins and salt flats to vibrant cities and breathtaking landscapes, the continent provides endless opportunities for adventure. By planning your route carefully, packing smart, and being open to new experiences, you’ll create unforgettable memories on your backpacking journey across South America.
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Jyoti Prakash
An insightful voice in the industry, crafting content that informs, inspires, and connects with readers.
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